While many medications have been find to be effective in alleviating the core symptoms of ADHD, no one treatment is right for everyone. Some people find that behavioral therapy is more helpful while others do better on medication. Modafinil 200 mg is a wakefulness-promoting drug that has been show to improve attention and response inhibition in clinical trials of psychiatric populations. It also appears to enhance the performance of a visual discrimination learning task that is dependent on front-cortical systems.
Lack of Long-Term Studies
Although the FDA has approved stimulants like Adderall for ADHD, a significant percentage of patients do not respond to these drugs. This calls for alternative treatments that work in a different way to enhance cognition and reduce fatigue. Modafinil 200 mg, a wakefulness-promoting drug that is not a classic sympathomimetic stimulant, may help to alleviate ADHD symptoms by increasing dopamine levels in the brain. However, the potential for misuse and its limited efficacy in managing core ADHD symptoms limit its use.
In several clinical trials, Modafinil has been show to improve symptoms of ADHD in children and adolescents. It has also been demonstrating to have a more favorable side-effect profile than classical stimulants. It has been report to have a less pronounced cardiovascular risk and a lower liability for abuse.
Three double-blind, placebo-controlled studies have found that 85 mg of Modafinil 200 mg administered in the form of a once-daily tablet improved teacher and parent ratings of ADHD symptoms as well as impulsivity and inattentiveness in children and adolescents with ADHD. In one study, Modafinil-treated children performed better on the Verbal Span and Strop tests than control groups.
These improvements were largely due to increased dopamine levels in the brain. Dopamine is a hormone that helps the brain focus and concentrate and has been link to motivation and reward. The increase in dopamine from Modafinil makes it easier to stay focused and attentive, which has a positive impact on ADHD symptoms.
The three studies used flexible-dose studies and titrated the dosages upward rather than using a fixed dose as in the 7-week fixed-dose study. This allowed for a faster onset of efficacy while also minimizing the frequency of adverse events.
Despite these positive findings, many medical professionals remain skeptical of the efficacy and safety of Modafinil for treating ADHD. At a recent FDA panel meeting on the drug, scientists from the Agency’s Center for Drug Evaluation and Research raised concerns about long-term safety and efficacy. In particular, one FDA scientist, Glen Manheim, described a child who developed severe skin rashes as a result of taking the drug, including blistering and peeling of the lips and urinary tract.
Potential for Misuse
As with any drug, there is a risk of misuse and addiction. Although it has very low abuse potential compared to other drugs like methylphenidate and amphetamines, Modafinil 200 mg may still cause dependence if taken for long periods of time. Some people who take this medication for off-label purposes may use it to get high, although this is very rare. In addition, this drug may interfere with some medications, so it is important to discuss its uses with a doctor before taking it.
Modalert Australia has the potential to increase dopamine concentrations in the brain by inhibiting dopamine reuptake. This can result in the same stimulant effects as other drugs use to treat ADHD, but without the feelings of euphoria that are usually associate with cocaine or methamphetamine use. However, it is not likely that this drug will cause any physical or psychological addiction, as it does not stimulate the same parts of the brain as a sympathomimetic stimulant.
The United States Food and Drug Administration has classified Modafinil as a Schedule IV drug, meaning that it has a low potential for abuse and does not pose a significant risk of harm to the user. This is a far lower classification than many other prescription medications, including some used to treat ADHD. Moreover, it is not likely that this drug will show up on a standard drug test because it has a different chemical makeup than amphetamines.
In addition, studies on animals have shown that Modafinil does not increase activity in the nucleus acumens, which is responsible for the rewarding effects of cocaine and other stimulants. However, in human studies, there has been some evidence that Modafinil does increase dopamine levels, especially in the prefrontal cortex.
This is a region that controls memory and attention, and it is not surprising that Modafinil has effects on these areas of the brain. It is also possible that this drug increases histamine levels, which are involved in attention and decision-making. However, these findings have not been confirmed in clinical trials on humans.
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