CB2, short for cannabinoid receptor type 2, is one of the two primary types of cannabinoid receptors found in the endocannabinoid system (ECS) of the human body. The other primary receptor is CB1, or cannabinoid receptor type 1.
These receptors play a crucial role in how the body interacts with cannabinoids, including both endocannabinoids produced naturally by the body and phytocannabinoids found in plants like cannabis.
Here are some key points about CB2 receptors:
- CB2 receptors are primarily found in the peripheral tissues of the body, particularly in the immune system cells, the gastrointestinal tract, the spleen, and other organs associated with the immune response.
- They are less prevalent in the central nervous system (CNS) compared to CB1 receptors, which are abundant in the cb2 brain and CNS.
- CB2 receptors are primarily associated with modulating the immune response and have anti-inflammatory and immunomodulatory properties.
- Activation of CB2 receptors can help regulate immune cell activity and reduce inflammation in various tissues.
- CB2 receptors interact with endocannabinoids, which are cannabinoids produced naturally within the body. One of the primary endocannabinoids that binds to CB2 receptors is called 2-arachidonoylglycerol (2-AG).